|
KMID : 0380319910470000115
|
|
Journal of Korean Research Institute for Better Living
1991 Volume.47 No. 0 p.115 ~ p.120
|
|
|
Variation of Marrow Granulocyte Reserve Depending on Age
|
|
|
|
|
Abstract
|
|
|
The frequency of bone manow depression is relatively high in old aged patients who receive anticancer chemotherapy, either therapy delay or drug dosage reduction is often required. The marrow granulocyte reserve(MGR) is the granulocyte pool in the bone marrow. From this pool, granulocytes are released to the peripheral blood upon receiving stress.
In this research, the variation of the marrow granulocyte reserve depending on age has been studied. The marrow granulocyte reserve was determined by the measurement of the increased granulocyte count in the peripheral blood after administration of prednisolone.
In 68 patients whose age were between 24 and 75, both the total and differential leukocyte count were measured immediately before and 5 hours after oral administration of 40 ㎎ of prednisolone.
The results obtained are as follows :
1) Initial granulocyte count in 68 patients before prednisolone administration was 3763±1415/㎣(range 1036―8848/㎣). After prednisolone administration, increment of the granulocyte count was 2700±1535/㎣(range 170―8745/㎣).
2) There was no correlation between the marrow granulocyte reserve and the initial granuloyte count in the peripheral blood(r=-0.158, 0.1＜p＜0.2).
3) The marrow granulocyte reserve decreases significantly as age increases(r=-0.536, p＜0.001).
In conclusion the marrow granulocyte reserve decrease as age increases. The measurement of the marrow granulocyte reserve can be useful either to predict or determine the level of the bone marrow depression during administration of drugs which affect the function of the bone marrow. In addition the measurement of MGR can be used as an indicator to determine the proper dosage and treatment interval depending on age.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|